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Ellagic acid
E2250 -
≥95% (HPLC), powder, from tree bark
DOWNLOAD MSDS (PDF)Synonym: 4,4′,5,5′,6,6′-Hexahydroxydiphenic acid 2,6,2′,6′-dilactone
CAS Number: 476-66-4
Empirical Formula (Hill Notation): C14H6O8
Molecular Weight: 302.19
Beilstein Registry Number: 47549
EC Number: 207-508-3
MDL number: MFCD00006914
PubChem Substance ID: 24894460
Properties
| Related Categories | Antioxidant and Free Radical Scavengers, Antioxidants and Cytoprotectants, Bioactive Small Molecules, Biochemicals Found in Plants - sorted by compound type, Biochemicals Found in Plants - sorted by plant name, |
| biological source | from tree bark |
| assay | ≥95% (HPLC) |
| form | powder |
| solubility | 1 M NaOH: soluble10 mg/mL, dark green |
| Gene Information | Research your gene in Your Favorite Gene powered by Ingenuity human ... CSK(1445), DYRK1A(1859), GSK3B(2932), SRC(6714) rat ... Lyn(81515), Syk(25155) |
Description
Biochem/physiol Actions
Commonly occurring plant polyphenol, inhibitor of glutathione S-transferase.1 Used for the assay of factor XIIa in plasma.2 Contact activation in blood coagulation.3
A naturally occurring plant phenol that is a potent antioxidant presumably by acting as a scavenger of oxygen species produced by hydrogen peroxide treatment, and as a protector of the DNA double helix from alkylating agent injury. It therefore has anti-mutagenic and anti-carcinogenic properties. Also reported to inhibit topoisomerases I and II and gyrase.
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Certificate of Analysis
Certificate of Origin
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Safety Information
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | DJ2620000 |
Technical information & documentation associated with this product is available in the Safety & Documentation tab.
References
1. M. Das et al. Biochem. Biophys. Res. Commun. 120, 427, (1984)
2. C. Kluft et al. Adv. Exp. Med. Biol. 156A, 201, (1983)
3. Exner, T. and Rickard, K.A. Thromb. Res. 26, 83, (1982)
Majid, S., et al., Influence of ellagic acid on antioxidant defense system and lipid peroxidation in mice. Biochem. Pharmacol. 42, 1441-1445, (1991) Abstract
Gali, H.U., et al., Hydrolyzable tannins: potent inhibitors of hydroperoxide production and tumor promotion in mouse skin treated with 12-O-tetradecanoylphorbol 13-acetate in vivo. Int. J. Cancer 51, 425-432, (1992) Abstract
Cozzi, R., et al., Taurine and ellagic acid: two differently-acting natural antioxidants. Environ. Mol. Mutagen. 26, 248-254, (1995) Abstract
Castonguay, A., et al., Biodistribution of, antimutagenic efficacies in Salmonella typhimurium of, and inhibition of P450 activities by ellagic acid and one analogue. Chem. Res. Toxicol. 11, 1258-1264, (1998) Abstract
Hayatsu, H., et al., Dietary inhibitors of mutagenesis and carcinogenesis. Mutat. Res. 202, 429-446, (1988) Abstract
Constantinou, A., et al., The dietary anticancer agent ellagic acid is a potent inhibitor of DNA topoisomerases in vitro. Nutr. Cancer 23, 121-130, (1995) Abstract
Weinder-Wells, M.A., et al., DNA gyrase inhibitory activity of ellagic acid derivatives. Bioorg. Med. Chem. Lett. 8, 97-100, (1998) Abstract
Merck 14,3547
Beil. 19,V,7,108
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